Amine-PEG-acid，NH2-PEG-COOH

Amine (polyethylene glycol) Carboxylic acid

Synonym: Amine PEGacid, Carboxylic acid PEG amine, HOOC-PEG-NH2

ProductStructure:

ProductSpecifications:

l CatalogNumbers:PS2-NCM-400,600, 1K,2K,3.4K, 5K, 10K.

l Appearance: White/off-whitesolid, semi-solid or liquid depends on molecular weight.

l Solubility: 10mg/mL in water,chloroform, DMSO.

l Stability: 1 Years at -20°C, Desiccate.

l CASNumber: -

l LinearFormula：H2NCH2CH2(CH2CH2O)nCH2COOH.

l MolecularWeight（PEG）: 400,600,1K,2K,3.4K, 5K, 10K.

l Reactivegroup: NH2.COOH

l Reactiveto: COOH,NHS.NH2

l Purity:> 95%.

Description:

NH2-PEG-COOH is a heterobifunctionalPEG crosslinkers that can be used to attach functional PEGs to biomolecules,particles and other materials surfaces. Carboxylic group reacts with aminegroup to form a stable amide bond. It can also react with hydroxyl group toform a labile ester bond. Amine groups, on the other hand, can be used for reactionswith many amine reactive groups, such as succinimidyl NHS ester, aldehyde, etc.PEG chain between amino and carboxyl group offers better water solubility andflexible linker length. PEGylation can increase solubility of modifiedmaterials. It can also increase stability and reduce immunogenicity of pegylatedpeptides and proteins. In addition, pegylation suppresses the non-specificbinding of charged molecules to the modified surfaces.

Handlingand Use:

NH2-PEG-COOH  is sensitive to light and temperature. Forbest use, material should always be kept in low temperature in dry condition.

 Avoid frequent thaw and freezing. For moreinformation about using this product, visit www.ponsure.com.

StorageConditions：

NH2-PEG-COOH should bestored at -20℃.Desiccate.  Materials may be handledunder inert gas for best stability. Re-testmaterial after 12 months.

References：

l ApH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode MagneticResonance Imaging and Chemotherapy ------ ACS Nano (IF=13.709)

l PEGylatedand CD47-conjugated nanoellipsoidal artificial antigen-presenting cellsminimize phagocytosis and augment anti-tumor T-cell responses------ InternationalJournal of Nanomedicine(IF=4.37)

l RGDpeptide-modified, paclitaxel prodrug-based, dual-drugs loaded, andredox-sensitive lipid-polymer nanoparticles for the enhanced lung cancertherapy------ Biomedicine & Pharmacotherapy(IF=3.457)

l Transcriptionactivator, hyaluronic acid and tocopheryl succinate multi-functionalized novellipid carriers encapsulating etoposide for lymphoma therapy------Biomedicine& Pharmacotherapy(IF=3.457)

l Folate-ConjugatedHalloysite Nanotubes, an Efficient Drug Carrier, Deliver Doxorubicin forTargeted Therapy of Breast Cancer------ ACSApplied Nano Materials.

RelatedProducts:

BIOTIN-PEG-NH2, DSPE-PEG-NH2

NH2-PEG-SH ,FA-PEG-NH2

FITC-PEG-NH2,LA-PEG-NH2

Thisproduct is for research use only and is not intended for use in humans or fordiagnostic use.