DSPE-PEG-Folate，DSPE-PEG-FA

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)]

Synonym: DSPE PEG Folate, Folic acid PEG DSPE

Product Structure:

Product Specifications:

l  Catalog Numbers:PS2-DEFA-1K,2K,3K,5K,10K.

l  Appearance:Yellow, orange to brownish solid.

l  Solubility:>5 mg/mL in hot water, chloroform/methanol, and DMSO.

l  Stability: 1 Years at-20°C, Desiccate. Protect from light.

l  CAS Number:1236288-25-7

l  Molecular Weight（PEG）:1K,2K,3.4K,5K,10K

Description:

DSPE PEG Folate, also called Folic acid PEG DSPE, is one of functional phospholipid PEG products provided by Ponsure for targeted drug delivery, nanoparticle functionalization, liposome formation as well as many other applications.Pegylated phospholipid products demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule targted delivery. DSPE (1,2-distearoyl-sn-glycero-3-phosphophoethanolamine) PEG folic acid is a C18 phospholipid PEG derivative which can be used for folate receptor targeting. Folic acid is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for numerous biological functions. It participates in the synthesis, repairing and methylation of DNA as well as to act as a cofactor in many biological reactions.Pegylated DSPE and Folic acid is soluble both in organic solvents and aqueous buffer. They have been used for preparing folate receptor targeting liposome for either small molecules or large molecules delivery. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs; it also suppresses the non-specific binding of charged molecules to the modified surfaces.

Handling and Use:

DSPE-PEG-FA should always be kept in low temperature in dry condition. Prepare fresh solution right before use.

Avoid frequent thaw and freezing. For more information about using this product, visit www.ponsure.com.

Related Products:

DSPE-PEG-NH2, DSPE-PEG-COOH

DSPE-PEG-NHS ,DSPE-PEG-FA

DSPE-PEG-SH,DSPE-PEG-MAL

References：

l  Bubble-generating nano-lipid carriers for ultrasound/CT imaging-guided efficient tumor therapy------ International Journal of Pharmaceutics（IF=3.862）

l  Nasopharyngeal cancer combination chemoradiation therapy based on folic acid modified, gefitinib and yttrium 90 co-loaded, core-shell structured lipid-polymer hybrid nanoparticles------ Biomedicine & Pharmacotherapy（IF=3.457）

l  Targeted delivery of in situ PCR-amplified Sleeping Beauty transposon genes to cancer cells with lipid-based nanoparticle-like protocells------ Biomaterials（IF=10.273）

l  Cancer cell targeting, controlled drug release and intracellular fate of biomimetic membrane-encapsulated drug-loaded nano-graphene oxide nanohybrids------ Journal of Materials Chemistry B（IF=4.776）

l  In vitro and in vivo evaluation of folate-mediated PEGylated nanostructured lipid carriers for the efficient delivery of furanodiene.

l  NIR stimulus-responsive core–shell type nanoparticles based on photothermal conversion for enhanced antitumor efficacy through chemo-photothermal therapy------ Nanotechnology(IF=3.404)

l  lipid nanobubbles as an ultrasound-triggered artesunate delivery system for imaging-guided,tumor-targeted chemotherapy.

l  Facile synthesis of biocompatible MoSe₂ nanoparticles for efficient targeted photothermal therapy of human lung cancer------ RSC Advances（IF=2.963）

l  Inhalable dry powder prepared from folic acid-conjugated Docetaxel liposomes alters pharmacodynamic and pharmacokinetic properties relevant to lung cancer chemotherapy.

l  Near infrared radiated stimulus-responsive liposomes based on photothermal conversion as drug carriers for co-delivery of CJM126 and cisplatin------ Materials Science and Engineering C（IF=5.08）

l  Normalizing Tumor Microenvironment Based on Photosynthetic Abiotic/Biotic Nanoparticles------ ACS Nano（13.709）

l  A novel near-infrared triggered dual-targeted nanoplatform for mitochondrial combined photothermal-chemotherapy of cancer in vitro------ Nanotechnology（3.404）

l  Folate-decorated and NIR-triggered nanoparticles loaded with platinum(IV)-prodrug plus 5-fluorouracil for targeted and chemo-photothermal combination therapy.

l  Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy------ RSC Advances（IF=2.963）

This product is for research use only and is not intended for use in humans or for diagnostic use.