DSPE-PEG-NHS，DSPE-PEG-SS

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[Succinimidyl Succinate ester(polyethylene glycol)]

Synonym: 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine PEG NHS, NHS PEG DSPE, DSPE PEG Succinimidyl Succinate ester, DSPE Polyethylene glycol NHS.

Product Structure:

Product Specifications:

l  Catalog Numbers:PS2-HDE-1K,2K,3K,5K,10K.

l  Appearance: White to off-white solid.

l  Solubility: 10 mg/mL in hot water, chloroform, DCM, DMSO.

l  Stability: 1 Years at-20°C, Desiccate.

l  CAS Number: -

l  Molecular Weight（PEG）:1K,2K,3.4K,5K,10K.

l  Reactive group: NHS.

l  Reactive to: Primary amine (-NH2).

l  Purity: 95%.

Description:

DSPE-PEG-NHS is one of Ponsure reactive phospholipid PEG conjugates that can react with primary amine groups. DSPE(1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. PEG backbone, on the other hand, offers good hydrophilicity and water solubility. Succinimidyl ester (NHS) on the PEG terminal reacts with primary amine groups efficiently at pH 8~10. DSPE-PEG-NHS can be easily incorporated into liposome and other nanoparticles. DSPE-PEG-NHS is one of most commonly used reactive phospholipids to conjugate antibodies, peptides or other ligands to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated molecules.

Handling and Use:

DSPE PEG NHS should always be kept in low temperature in dry condition. Prepare fresh solution right before use.Avoid frequent thaw and freezing. For more information about using this product,  visit www.ponsure.com.

Related Products:

DSPE-PEG-NH2, DSPE-PEG-COOH

DSPE-PEG-N3 ,DSPE-PEG-FA

DSPE-PEG-SH,DSPE-PEG-MAL

References：

l  Biomimetic virus-like and charge reversible nanoparticles to sequentially overcome mucus and epithelial barriers for oral insulin delivery------ Acs applied  materials&interfaces（IF=8.097）

l  The combination of endolysosomal escape and basolateral stimulation to overcome the difficulties of “easy uptake hard transcytosis” of ligand-modified nanoparticles in oral drug delivery------ Nanoscale（IF=7.233）

l  Colorimetric in situ assay of membrane-bound enzyme based on lipid bilayer inhibition of ion transport------ Theranostics（IF=8.537）

This product is for research use only and is not intended for use in humans or for diagnostic use.