Folic acid-PEG-NHS，FA-PEG-NHS

NHS (polyethylene glycol) folic acid

Synonym: Folate PEG NHS, NHS PEG Folate, NHS PEG Folic acid

Product Structure:

Product Specifications:

l  Catalog Numbers:PS2-HFA-1K,2K,3.4K,5K,10K.

l  Appearance: Orange/yellow to brownish solid.

l  Solubility: DMSO.

l  Stability: 1 Years at-20°C, Desiccate. Protect from light.

l  CAS Number:-

l  Molecular Weight（PEG）: 1K,2K,3.4K,5K,10K.

l  Reactive group: NHS.

Description:

FA-PEG-NHS is one of Ponsure amine reactive folate PEG derivatives that have a folic acid on one terminus of PEG chain and a succinimidyl NHS group on the other PEG end. Folic acid is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for numerous biological functions. It participates in the synthesis, repairing and methylation of DNA as well as to act as a cofactor in many biological reactions. NHS functionalized folic acid PEG enables attachment of folic acid to amine groups from other molecules or materials quickly and efficiently. NHS reacts with primary amine group at elevated pH to form a stable amide bond. Flexible PEG chain between NHS and folate offers better water solubility, less steric hindrance and higher stability. Molecules or materials conjugated with PEG folic acid are useful for targeted drug delivery, cellular imaging and bioassay development. 

Handling and Use:

FA-PEG-NHS  is sensitive to light and temperature. For best use, material should always be kept in low temperature in dry condition. Protect from light.

 Avoid frequent thaw and freezing. For more information about using this product, visit www.ponsure.com.

Storage Conditions：

FA-PEG-NHS should be stored at -20℃. Desiccate. Protect from light. Materials may be handled under inert gas for best stability.

References：

l  Acta Biomaterialia------ Folic acid modified cell membrane capsules encapsulated doxorubicin and indocyanine green for highly effective combinational therapy in vivo.

l  Sensors and Actuators B: Chemical------ Affordable and simple method for separating and detecting ovarian cancer circulating tumor cells using BSA coated magnetic nanoprobes modified with folic acid.

l  Nanoscale Research Letters------ Tumor-Targeted and Biocompatible MoSe2 Nanodots@Albumin Nanospheres as a Dual-Modality Therapy Agent for Synergistic Photothermal Radiotherapy.

Related Products:

FA-PEG-COOH, FA-PEG-FITC

FA-PEG-Maleimide ,FA-PEG-SH

FA-PEG-NH2,DSPE-PEG-FA

This product is for research use only and is not intended for use in humans or for diagnostic use.