英文简称：Methoxy (polyethylene glycol) Carboxylic acid
Methoxy (polyethylene glycol) Carboxylic acid
Synonym: mPEG-COOH, mPEG acid, Methoxypolyethylene glycol acid, PEG acid
l Catalog Numbers:PS1-CM-350,550,750,1k,2k,5k,10k,20k,30k.
l Appearance: White/off-white solid, semi-solid or liquid depends on molecular weight.
l Solubility: 10 mg/mL in water,chloroform, DMSO.
l Stability: 1 Years at -20°C, Desiccate.
l Linear Formula：CH3O(CH2CH2O)nCH2COOH.
l Molecular Weight（PEG）: 350,550,750,1k,2k,5k,10k,20k,30k.
l Reactive group: COOH
l Reactive to: NH2
l Purity: > 95%.
MPEG-COOH is one of Ponsure carboxylic acid (-COOH) functionalized polyethylene glycol derivatives that can be used to modify proteins, peptides, particles and other materials with their free acid group. Carboxylic acid groups react readily with amine groups to form stable amide bond. They can also react with hydroxyl groups to form labile ester bond which can be cleaved under acidic or basic conditions. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces. Acid functionalized PEG has broad applications in the field of medical device modification, biomolecule pegylation and particle surface functionalization.
Handling and Use:
MPEG-COOH is sensitive to light and temperature. For best use, material should always be kept in low temperature in dry condition.
Avoid frequent thaw and freezing. For more information about using this product, visit www.ponsure.com.
MPEG-COOH should be stored at -20℃. Desiccate. Materials may be handled under inert gas for best stability. Re-test material after 12 months.
l Size Changeable Nanosystems for Precise Drug Controlled Release and Efficient Overcoming of Cancer Multidrug Resistance------Journal of Materials Chemistry B (IF=4.776)
l Angiopep-2 modified PEGylated 2-methoxyestradiol micelles to treat the PC12 cells with oxygen-glucose deprivation/reoxygenation------Colloids and Surfaces B: Biointerfaces (IF=3.997)
l PEGylated doxorubicin cloaked nano-graphene oxide for dual-responsive photochemical therapy ------ International Journal of Pharmaceutics (IF=3.862)
This product is for research use only and is not intended for use in humans or for diagnostic use.