DSPE-PEG-DBCO

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[dibenzocyclooctyl(polyethyleneglycol)].

Synonym: 1,2-Distearoyl-sn-glycero-3-phosphoethanolaminePEG DBCO, DBCO-PEG-DSPE.

ProductStructure:

ProductSpecifications:

l CatalogNumbers:PS2-DBDE-1K,2K,3K,5K,10K.

l Appearance: Whiteto off-white or Pale yellow solid.

l Solubility: >5mg/mL in hot water, chloroform, DCM.

l Stability: 1 Years at-20°C, Desiccate.

l CASNumber: 2052955-83-4.

l MolecularWeight（PEG）:1K,2K,3.4K,5K,10K.

l Reactivegroup: DBCO.

l Purity: 95%.

Description:

DSPE-PEG-DBCO is one ofPonsure reactive phospholipid PEG derivatives that can go Click Chemistryreaction with azide group. DBCO (dibenzocyclooctyne) is a commonly used copperfree Click Chemistry reagent that has quick and specific reactivity towardazide (-N3) containing molecules. DBCO PEG derivatives possess fast kineticsand good stability in aqueous buffer. Reaction between DBCO and azide group allowsthe labeling and conjugation of DSPE to targeted substrates with highefficiency. DSPE (1,2-distearoyl-sn-glycero-3-phosphophoethanolamine) is an 18carbon saturated phospholipid that is highly hydrophobic. Pegylatedphospholipids are excellent liposome formulation materials that can be used formolecule encapsultion, gene transfection and drug delivery. Pegylation ofphospholipids with DSPE-PEG-DBCO significantlyimproves the blood circulation time and stability for encapsulated drugs.

Cu-free clickchemistry with readily synthesized biarylazacyclooctynones. The reaction ofazides with strained alkynes, such as cyclooctynes, readily forms a triazoleproduct without the need for a toxic catalyst.

Refer also toDSPE-PEG Azide Ponsure Number PS2-AZDE.

Handlingand Use:

For best use, DSPE-PEG-DBCO should be kept in lowtemperature in dry condition. Prepare fresh solution right before use. Avoidfrequent thaw and freezing. For more information about using this product,  visit www.ponsure.com.

RelatedProducts:

DSPE-PEG-NH2,DSPE-PEG-COOH

DSPE-PEG-NHS,DSPE-PEG-FA

DSPE-PEG-SH,DSPE-PEG-MAL

References：

l Voxel-BasedDosimetry of Iron Oxide Nanoparticle-Conjugated 177Lu-Labeled Folic Acid UsingSPECT/CT Imaging of Mice.

l RapidCu-free click chemistry with readily synthesized biarylazacyclooctynones.

l ArtificialMembrane Fusion Triggered by Strain-Promoted Alkyne-Azide Cycloaddition.

RelatedProducts:

DBCO-PEG-COOH, DBCO-PEG-NH2

DBCO-PEG-SH ,DBCO-PEG-MAL

DBCO-PEG-NHS,MPEG-DBCO

Thisproduct is for research use only and is not intended for use in humans or fordiagnostic use.