DSPE-PEG-Azide, DSPE-PEG-N3

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)]

Synonym: Azide PEG DSPE，N3-PEG-DSPE.

Product Structure:

Product Specifications:

l  Catalog Numbers:PS2-DEAZ-1K,2K,3K,5K,10K.

l  Appearance: White to off-white solid.

l  Solubility: >10 mg/mL in hot water, chloroform, DCM, Methanol.

l  Stability: 1 Years at-20°C, Desiccate.

l  CAS Number: 1938081-40-3.

l  Molecular Weight（PEG）:1K,2K,3.4K,5K,10K.

l  Purity: 95%.

Description:

1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated Polyethylene Glycol, DSPE PEG is a phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Ponsure DSPE-PEG-N3 products can be used to prepare pegylated liposome using Click Chemistry. Azide reacts readily with alkyne or cycloocytne in aqueous solution with or without copper catalyst. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs.

Cu-free click chemistry with readily synthesized biarylazacyclooctynones. The reaction of azides with strained alkynes, such as cyclooctynes, readily forms a triazole product without the need for a toxic catalyst.

Refer also to DSPE-PEG-DBCO Ponsure Number PS2-AZDE

Handling and Use:

DSPE PEG Azide should always be kept in low temperature in dry condition. Prepare fresh solution right before use.Avoid frequent thaw and freezing. For more information about using this product,  visit www.ponsure.com.

Related Products:

DSPE-PEG-NH2, DSPE-PEG-COOH

DSPE-PEG-NHS ,DSPE-PEG-FA

DSPE-PEG-SH,DSPE-PEG-MAL

References：

l  Hood ED, Greineder CF, Shuvaeva T, Walsh L, Villa CH, Muzykantov VR. Vascular targeting of radiolabeled liposomes with bio-orthogonally conjugated ligands: single chain fragments provide higher specificity than antibodies.

This product is for research use only and is not intended for use in humans or for diagnostic use.