DSPE-PEG-COOH，DSPE-PEG-Acid

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)]

Synonym: DSPE PEG acid, Carboxylic PEG DSPE

Product Structure:

Product Specifications:

l  Catalog Numbers:PS2-CMDE-1K,2K,3K,5K,10K.

l  Appearance: White to off-white solid.

l  Solubility: >10 mg/mL in hot water, chloroform, DCM.

l  Stability: 1 Years at-20°C, Desiccate.

l  CAS Number: 1403744-37-5

l  Molecular Weight（PEG）:1K,2K,3.4K,5K,10K

l  Reactive group: Carboxylic acid (-COOH).

l  Reactive to: Primary amine group (-NH2)

l  Purity: 95%.

Description:

DSPE and acid is one of Ponsure reactive phospholipid PEG derivatives. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. PEG backbone, on the other hand, offers good hydrophilicity and water solubility. Carboxylic functionalized DSPE PEG has excellent reactivity towards amine or hydryoxyl groups. Carboxylic PEG DSPE is one of most commonly used reactive phospholipids to conjugate antibodies,peptides or other ligands to the surface of liposome and other lipid nanoparticles. Pegylation of phospholipids significantly increases the blood circulation time and stability for encapsulated drugs. Ponsure has developed a comprehensive collection of reactive phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule labeling, formulation and delivery.

Handling and Use:

DSPE PEG acid should always be kept in low temperature in dry condition. Prepare fresh solution right before use.Avoid frequent thaw and freezing. For more information about using this product,  visit www.ponsure.com.

Related Products:

DSPE-PEG-NH2, DSPE-PEG-OPSS

DSPE-PEG-NHS ,DSPE-PEG-FA

DSPE-PEG-SH,DSPE-PEG-MAL

References：

l  Transport mechanisms of butyrate modified nanoparticles: insight into “easy entry, hard transcytosis” of active targeting system in oral administration------Molecular pharmaceutics(IF=4.556)

l  Enhanced cellular uptake of near-infrared triggered targeted nanoparticles by cell penetrating peptide TAT for combined chemo/photothermal/photodynamic therapy------ Materials Science and Engineering C(IF=5.08)

l  Bioinspired butyrate-functionalized nanovehicles for targeted oral delivery of biomacromolecular drugs------ Journal of Controlled Release（IF=7.877）

l  NIR stimulus-responsive core–shell type nanoparticles based on photothermal conversion for enhanced antitumor efficacy through chemo-photothermal therapy------ Nanotechnology（IF=3.404）

l  lipid nanobubbles as an ultrasound-triggered artesunate delivery system for imaging-guided,tumor-targeted chemotherapy------ OncoTargets and Therapy(IF=2.656)

l  Facile synthesis of biocompatible MoSe₂ nanoparticles for efficient targeted photothermal therapy of human lung cancer------ RSC Advances（IF=2.963）

l  Biomimetic virus-like and charge reversible nanoparticles to sequentially overcome mucus and epithelial barriers for oral insulin delivery------Acs applied  materials&interfaces（IF=8.097）

l  A novel near-infrared triggered dual-targeted nanoplatform for mitochondrial combined photothermal-chemotherapy of cancer in vitro------Nanotechnology（IF=3.404）

l  Stable Gold Nanorods Conjugated Liposomal Podophyllotoxin Nanocomposites for Synergistic Chemo-Photothermal Cancer Therapy------Journal of Biomedical Nanotechnology(5.068)

This product is for research use only and is not intended for use in humans or for diagnostic use.