DSPE-PEG-Maleimide, DSPE-PEG-MAL

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)]

Synonym: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-polyethylene glycol maleimide, Maleimide PEG DSPE.

Product Structure:

Product Specifications:

l  Catalog Numbers:PS2-MDE-1K,2K,3K,5K,10K.

l  Appearance: White to off-white or yellowish-white solid.

l  Solubility: >10 mg/mL in hot water, chloroform, DCM, methanol.

l  Stability: 1 Years at-20°C, Desiccate.

l  CAS Number: 474922-22-0.

l  Molecular Weight（PEG）:1K,2K,3.4K,5K,10K.

l  Reactive group: Maleimide (-MAL).

l  Reactive to: Sulfhydryl (-SH).

l  Purity: 95%.

Description:

DSPE PEG Maleimide is one of Ponsure reactive phospholipid PEG derivatives that can react with sulfhydryl groups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. PEG backbone, on the other hand, offers good hydrophilicity and water solubility. Maleimide functionalized DSPE PEG has excellent reactivity towards sulfhydryl/thiol groups. Reaction between Maleimide and thiol group proceeds easily at neutral pH. Maleimide PEG DSPE is one of most commonly used reactive phospholipids to conjugate antibodies, peptides or other ligands to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated drugs. Ponsure has developed a comprehensive collection of thiol reactive maleimide phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule drug formulation and delivery.

Handling and Use:

DSPE PEG Maleimide undergoes hydrolysis at elevated temperature and moisture. Maleimide PEG should always be kept in low temperature in dry condition. Prepare fresh solution right before use. Avoid frequent thaw and freezing. For more information about using this product,  visit www.ponsure.com.

Related Products:

DSPE-PEG-NH2, DSPE-PEG-COOH

DSPE-PEG-NHS ,DSPE-PEG-FA

DSPE-PEG-SH,DSPE-PEG-OPSS

References：

l  Afatinib-loaded Immunoliposomes Functionalized with Cetuximab: a Novel Strategy Targeting the Epidermal Growth Factor Receptor for Treatment of Non-small-cell Lung Cancer------ International Journal of Pharmaceutics（IF=3.862）

l  Layer-by-Layer Heparinization of the Cell Surface by Using Heparin-Binding Peptide Functionalized Human Serum Albumin------ Materials(IF=2.467)

l  Lifetime-engineered NIR-II nanoparticles unlock multiplexed in vivo imaging------ Nature Nanotechnology(IF=37.49)

l  Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway------Acs applied  materials&interfaces（IF=8.097）

l  Biomimetic virus-like and charge reversible nanoparticles to sequentially overcome mucus and epithelial barriers for oral insulin delivery Acs applied  materials&interfaces（IF=8.097）

l  Enhanced legumain-recognition and NIR controlled released of cisplatin-indocyanine nanosphere against gastric carcinoma------ European Journal of Pharmacology（IF=3.04）

This product is for research use only and is not intended for use in humans or for diagnostic use.