Methoxy-PEG-NHS，MPEG-NHS

Methoxy (polyethylene glycol) SuccinimidylCarboxyl Methyl ester

Synonym: Methoxy PEGNHS, mPEG-NHS, mPEG SCM, NHS PEG

ProductStructure:

ProductSpecifications:

l CatalogNumbers:PS1-H-350,500,550,750,1K,2K,4K,5K,10K.20K,30K.

l Appearance: White/off-whitesolid, semi-solid or liquid depends on molecular weight.

l Solubility: 10mg/mL in water,chloroform, DMSO.

l Stability: 1 Years at -20°C, Desiccate.

l LinearFormula：CH3O(CH2CH2O)nCH2CH2NHS.

l MolecularWeight（PEG）: 350,500,550,750,1K,2K,3.4K,5K,10K.20K,30K.

l Reactivegroup: NHS.

l Reactiveto: NH2.

l Purity:> 95%.

Description:

mPEG-NHS  is an amine (-NH2) reactive PEG derivativethat can be used to modify proteins, antibodies, peptides and many othermaterials via their available amino groups. NHS esters react with primary aminegroup at pH 7~10 to form a stable amide bond. Reaction between NHS and amineallows fast and efficient attachment of PEG to reacting molecules. Compared toother PEG NHS ester derivatives, (mPEGNHS/SCM) ester offers superior reactivityand higher stability in aqueous solution. NHS PEG products provided by Ponsurehave high purity, narrow molecular weight distribution and excellent reactivity.Primary amines react with NHS PEG esters by nucleophilic attack and NHS isreleased as a byproduct. Hydrolysis of the NHS-ester competes with the reactionin aqueous solution and increases with increasing pH.

Handlingand Use:

mPEG-NHS  is sensitive to light and temperature. Forbest use, material should always be kept in low temperature in dry condition.

 Avoid frequent thaw and freezing. For moreinformation about using this product, visit www.ponsure.com.

StorageConditions：

mPEG-NHS should be stored at -20℃.Desiccate.  Materials may be handledunder inert gas for best stability. Re-testmaterial after 12 months.

References：

l DACHPt-LoadedUnimolecular Micelles Based on Hydrophilic Dendritic Block Copolymers forEnhanced Therapy of Lung Cancer------Acs applied  materials&interfaces (IF=8.097)

l MultifunctionalMicelles Dually Responsive to Hypoxia and Singlet Oxygen: Enhanced PhotodynamicTherapy via Interactively Triggered Photosensitizer Delivery ------ Acsapplied  materials&interfaces (IF=8.097)

l 99mTc-conjugatedmanganese-based mesoporous silica nanoparticles for SPECT, pH-responsive MRIand anti-cancer drug delivery------ Nanoscale (IF=7.233)

l TargetedDelivery of Docetaxel via Pi-Pi Stacking Stabilized  Dendritic Polymeric Micelles for EnhancedTherapy of Liver Cancer------Materials Science and Engineering C (IF=5.08)

l Functionalchlorin gold nanorods enable to treat breast cancer byphotothermal/photodynamic therapy------InternationalJournal of Nanomedicine (IF=4.37)

l Tumor-Targetedand Biocompatible MoSe2 Nanodots@Albumin Nanospheres as a Dual-Modality TherapyAgent for Synergistic Photothermal Radiotherapy------ NanoscaleResearch Letters (IF=3.125)

l AnIntelligent Nanoscale Insulin Delivery System------ Molecules (IF=3.098)

l DualPeptides Modified Fluorescence-SERS Dual Mode Imaging  Nanoprobes with Improved Cancer CellTargeting Efficiency------ RSC Advances (IF=2.963)

RelatedProducts:

NHS-PEG-COOH, DSPE-PEG-NHS

NHS-PEG-NHS ,FA-PEG-NHS

FITC-PEG-NHS,LA-PEG-NHS

Thisproduct is for research use only and is not intended for use in humans or fordiagnostic use.