Thiol-PEG-acid，HS-PEG-COOH

Thiol (polyethylene glycol) Carboxylic acid

Synonym: Thiol PEG acid, Carboxylic acid PEG Thiol, HOOC-PEG-SH

Product Structure:

Product Specifications:

l  Catalog Numbers:PS2-SCM-400,600, 1K,2K,3.4K, 5K, 10K.

l  Appearance: White/off-white or pale-yellow solid, semi-solid or liquid depends on molecular weight.

l  Solubility: 10 mg/mL in water,chloroform, DMSO.

l  Stability: 1 Years at -20°C, Desiccate.

l  Linear Formula：HSCH2CH2(CH2CH2O)nCH2COOH.

l  Molecular Weight（PEG）: 400,600, 1K,2K,3.4K, 5K, 10K.

l  Reactive group: SH.COOH

l  Reactive to: MAL,NH2

l  Purity: > 95%.

Description:

HS-PEG-COOH is one of Ponsure reactive thiol PEG derivatives that have a terminal carboxylic group. Carboxylic groups can react with amine or hydroxyl groups to form a stable amide bond or a labile ester bond. Reactions of carboxylic group allow the conversion of amine or hydroxyl groups to free thiols with a linear PEG linker. Resulted thiol groups can be used to modify gold nanoparticle surface or participate in other pegylation reactions. PEG linker between thiol and carboxylic group offers good water solubility, flexible linker distance and higher stability.

Handling and Use:

HS-PEG-COOH  is sensitive to light and temperature. For best use, material should always be kept in low temperature in dry condition.

 Avoid frequent thaw and freezing. For more information about using this product, visit www.ponsure.com.

Storage Conditions：

HS-PEG-COOH should be stored at -20℃. Desiccate.  Materials may be handled under inert gas for best stability. Re-test material after 12 months.

References：

l  A Light-Triggered Mesenchymal Stem Cell Delivery System for Photoacoustic Imaging and Chemo-Photothermal Therapy of Triple Negative Breast Cancer------ Advanced science (IF=12.441)

l  A para-Aminothiophenol Radical Reaction-Functionalized Gold Nanoprobe for One-to-All Detection of Five Reactive Oxygen Species in Vivo------Analytical Chemistry (IF=6.042)

l  Colorimetric and visual determination of acrylamide via------Microchim Acta (IF=5.705)

l  A novel disulfide bond-mediated cleavable RGD-modified PAMAM nanocomplex containing nuclear localization signal HMGB1 for enhancing gene transfection efficiency------ International Journal of Nanomedicine (IF=4.37)

Related Products:

BIOTIN-PEG-SH, DSPE-PEG-SH

NH2-PEG-SH ,FA-PEG-SH

HS-PEG-NHS,N3-PEG-SH

This product is for research use only and is not intended for use in humans or for diagnostic use.