Silane-PEG-acid，Silane-PEG-COOH

Silane (polyethylene glycol) Carboxylic acid

Synonym: Silane PEG acid, Carboxylic PEG Silane, Triethoxysilane PEG acid, Trimethoxysilane PEG acid

Product Structure:

Product Specifications:

l  Catalog Numbers:PS2-CML-1K,2K,3.4K,5K,10K.

l  Appearance: White/off-white pale-yellow solid.

l  Solubility: 10 mg/mL in water,chloroform, DMSO.

l  Stability: 6 months at -20°C, Desiccate.

l  Molecular Weight（PEG）: 1K,2K,3.4K, 5K, 10K.

l  Reactive group: COOH

l  Reactive to: NH2

Description:

Silane-PEG-COOH is one of Ponsure  surface reactive polyethylene glycol silanization and pegylation reagents that contain a terminal triethoxysilane and a carboxylic group. Silane PEG COOH can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and alkoxyl silane groups. Triethoxyl or trimethoxyl silane reacts with OH groups easily with catalytic amount of water. Meanwhile, carboxylic group can be activated to react with amine or hydroxy groups. PEG linker between alkoxysilane and maleimide group offers better water solubility, less steric hindrance and enhanced reactivity. Compared to other organic silanes, Nanocs’ silane PEGs are soluble in aqueous solution, all silanization reactions can be performed in aqueous solution without adding any organic solvents. Alkoxyl groups hydrolyze readily in aqueous solution and reaction can be completed at room temperature in 30~60 min.

Handling and Use:

Silane-PEG-COOH  is sensitive to light and temperature. For best use, material should always be kept in low temperature in dry condition.

 Avoid frequent thaw and freezing. For more information about using this product, visit www.ponsure.com.

Storage Conditions：

Silane-PEG-COOH should be stored at -20℃. Desiccate.  Materials may be handled under inert gas for best stability. Re-test material after 6 months.

References：

l  Functionalized Holmium-Doped Hollow Silica Nanospheres for Combined Sonodynamic and Hypoxia-Activated Therapy------Advanced functional materials (IF=13.325)

l  Identifying macrophage enrichment in atherosclerotic plaques by targeting dual-modal US imaging/MRI based on biodegradable Fe-doped hollow silica nanospheres conjugated with anti-CD68 antibody------Nanoscale (IF=7.233)

Related Products:

BIOTIN-PEG-COOH, DSPE-PEG-COOH

NH2-PEG-COOH ,FA-PEG-COOH

FITC-PEG-COOH,HS-PEG-COOH

This product is for research use only and is not intended for use in humans or for diagnostic use.