DSPE-PEG5000 ，MPEG5000-DSPE，384835-61-4

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)5000]

Synonym: Methoxy Polyethylene Glycol DSPE5000， MethoxyPEG5000 DSPE, mPEG5000 DSPE, PEG5000 DSPE, DSPE-MPEG5000.

Product Structure:

Product Specifications:

l  Catalog Numbers:PS1-DE-5K.

l  Appearance: White to off-white solid.

l  Solubility: >10 mg/mL in warm water, chloroform, DCM, methanol.

l  Stability: 2 Years at-20°C, Desiccate.

l  CAS Number: 384835-61-4.

l  Molecular Weight:5801.071 (average MW due to polydispersity of PEG).

l  Purity: ＞95%.

Description:

1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine with conjugated methoxyl poly(ethylene glycol) (DSPE-mPEG) is a linear phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. Pegylated phospholipids are excellent liposome or micelle formation materials that can be used for drug delivery. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

Handling and Use:

DSPE PEG5000(MPEG5000-DSPE) should always be kept in low temperature in dry condition. Prepare fresh solution right before use.Avoid frequent thaw and freezing. For more information about using this product,  visit www.ponsure.com. 

Related Products:

DSPE-PEG-NH2, DSPE-PEG-COOH

DSPE-PEG-NHS ,DSPE-PEG-FA

DSPE-PEG-SH,DSPE-PEG-MAL

References：

l  Ultrafast and Non-invasive Long-Term Bioimaging with Highly Stable Red Aggregation-Induced Emission Nanoparticles------ Analytical Chemistry（IF=6.042）

l  Ultra-small nanocluster mediated synthesis of Nd ³⁺ -doped core-shell nanocrystals with emission in the second near-infrared window for multimodal imaging of tumor vasculature------ Biomaterials(IF=10.273)

l  Novel small molecular dye-loaded lipid nanoparticles with efficient near-infrared-II absorption for photoacoustic imaging and photothermal therapy of hepatocellular carcinoma------ Biomaterials(IF=10.273)

l  Hybrid Nanoclusters for Near-Infrared to Near-Infrared Upconverted Persistent Luminescence Bioimaging------ Acs applied  materials&interfaces(IF=8.097)

l  Hierarchically Theranostic Nanomedicine: MRI Contrast Agents as the Physical Vehicle Anchor for High Drug Loading and Triggered on-demand Delivery------ Journal of Materials Chemistry B(IF=4.776)

l  Dual Near-Infrared Emissive Luminescent Nanoprobe for Ratiometric Luminescent Monitoring of ClO-in Living Organisms------ Acs applied  materials&interfaces(IF=8.097)

l  Near-Infrared Upconversion Luminescence and Bioimaging In Vivo Based on Quantum Dots------ Advanced science(IF=12.441)

l  Afatinib-loaded Immunoliposomes Functionalized with Cetuximab: a Novel Strategy Targeting the Epidermal Growth Factor Receptor for Treatment of Non-small-cell Lung Cancer------ International Journal of Pharmaceutics(IF=3.862)

l  Zinc phthalocyanine-soybean phospholipid complex based drug carrier for switchable photoacoustic/fluorescence image, multiphase photothermal/photodynamic treatment and synergetic therapy------Journal of Controlled Release(IF=7.877)

l  Mitoxantrone-preloaded water-responsive phospholipid-amorphous calcium carbonate hybrid nanoparticles for targeted and effective cancer therapy------ International Journal of Nanomedicine(IF=4.37)

l  Ultralong  Circulating  Choline  Phosphate Liposomal  Nanomedicines  for  Cascaded Chemo-Radiotherapy------ Biomaterials Science(IF=5.831)

l  Nano-biotinylated liposome-based immunoassay for the ultrasensitive detection of protein biomarker in urine------ Talanta(IF=4.244)

l  In vitro and in vivo evaluation of folate mediated PEGylated nanostructured lipid carriers for the efficient delivery of furanodiene.

l  Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway------Acs applied  materials&interfaces(IF=8.097)

l  Light/magnetic hyperthermia triggered drug released from multi-functional thermo-sensitive magnetoliposomes for precise cancer synergetic theranostics------Journal of Controlled Release(IF=7.877)

l  Novel theranostic zinc phthalocyanine–phospholipid complex self-assembled  nanoparticles  for  imaging-guided  targeted photodynamic treatment with controllable ROS production and shape-assisted enhanced cellular uptake------ Colloids and Surfaces B: Biointerfaces(IF=3.997)

l  Erythrocyte membrane camouflaged graphene oxide for tumor-targeted photothermal-chemotherapy------ Carbon(IF=7.082)

This product is for research use only and is not intended for use in humans or for diagnostic use.